Table 2 Comparisons of mean changes from baseline to 4 weeks in amyloid burden between treatment groups (white matter standard)
Bexarotene | Placebo | Difference | ||||
|---|---|---|---|---|---|---|
Factor | N | Mean (95 % CI) | N | Mean (95 % CI) | Mean (95 % CI) | p Value |
All subjects | ||||||
Composite | 16 | −0.028 (−0.064, 0.008) | 4 | 0.023 (−0.049, 0.096) | −0.052 (−0.133, 0.030) | 0.22 |
Frontal medial orbital | 16 | −0.043 (−0.081, −0.006) | 4 | −0.021 (−0.096, 0.054) | −0.022 (−0.106, 0.062) | 0.61 |
Anterior cingulate | 16 | −0.040 (−0.080, 0.000) | 4 | 0.018 (−0.061, 0.098) | −0.059 (−0.147, 0.030) | 0.20 |
Parietal | 16 | −0.003 (−0.034, 0.027) | 4 | 0.044 (−0.018, 0.105) | −0.047 (−0.116, 0.022) | 0.19 |
Posterior cingulate | 16 | −0.017 (−0.065, 0.031) | 4 | 0.044 (−0.052, 0.141) | −0.061 (−0.169, 0.047) | 0.27 |
Precuneus | 16 | −0.027 (−0.069, 0.014) | 4 | 0.040 (−0.043, 0.122) | −0.067 (−0.159, 0.025) | 0.16 |
Temporal | 16 | −0.038 (−0.075, 0.000) | 4 | 0.016 (−0.059, 0.090) | −0.053 (−0.136, 0.030) | 0.22 |
ApoE4 noncarriers | ||||||
Composite | 4 | −0.097 (−0.155, −0.040) | 3 | 0.047 (−0.019, 0.114) | −0.145 (−0.232, −0.057) | 0.012 |
Frontal medial orbital | 4 | −0.076 (−0.146, −0.007) | 3 | 0.005 (−0.075, 0.085) | −0.081 (−0.187, 0.025) | 0.16 |
Anterior cingulate | 4 | −0.096 (−0.166, −0.026) | 3 | 0.048 (−0.034, 0.129) | −0.143 (−0.251, −0.036) | 0.029 |
Parietal | 4 | −0.068 (−0.107, −0.029) | 3 | 0.065 (0.020, 0.110) | −0.133 (−0.193, −0.073) | 0.002 |
Posterior cingulate | 4 | −0.113 (−0.180, −0.046) | 3 | 0.074 (−0.004, 0.151) | −0.187 (−0.289, −0.084) | 0.007 |
Precuneus | 4 | −0.127 (−0.188, −0.066) | 3 | 0.062 (−0.008, 0.132) | −0.189 (−0.282, −0.096) | 0.004 |
Temporal | 4 | −0.104 (−0.162, −0.045) | 3 | 0.031 (−0.037, 0.098) | −0.134 (−0.224, −0.045) | 0.018 |
ApoE4 carriers | ||||||
Composite | 12 | −0.005 (−0.041, 0.031) | 1 | −0.048 (NA) | NA | NA |
Frontal medial orbital | 12 | −0.033 (−0.074, 0.009) | 1 | −0.099 (NA) | NA | NA |
Anterior cingulate | 12 | −0.022 (−0.062, 0.019) | 1 | −0.069 (NA) | NA | NA |
Parietal | 12 | 0.018 (−0.013, 0.050) | 1 | −0.019 (NA) | NA | NA |
Posterior cingulate | 12 | 0.015 (−0.035, 0.065) | 1 | −0.044 (NA) | NA | NA |
Precuneus | 12 | 0.006 (−0.031, 0.043) | 1 | −0.027 (NA) | NA | NA |
Temporal | 12 | −0.015 (−0.055, 0.024) | 1 | −0.030 (NA) | NA | NA |