Brain metabolism and cerebrospinal fluid biomarkers profile of non-amnestic mild cognitive impairment in comparison to amnestic mild cognitive impairment and normal older subjects

Table 2 rBGM comparison between aMCI, naMCI, and CG using SPM8^a. Results showing areas of rBGM reduction

	Z score	p value	Cluster size (number of voxels)	Peak voxel coordinates (Talairach)
aMCI × CG^b
Left middle temporal gyrus, BA39	3.51	<0.001	41	−46	−67	20
Left precuneus, BA31	3.17	<0.001	33	−4	−51	32
Left precuneus, BA7	3.33	<0.001	15	−2	−63	64
aMCI × naMCI^b
Left temporal lobe	3.62	<0.001	167	−44	−45	2
naMCI × control group^b
Right inferior frontal gyrus, BA9	3.80	<0.001	34	46	11	29
Right middle frontal gyrus, BA9	3.40	<0.001	51	34	34	28
Right middle frontal gyrus, BA8	3.32	<0.001	51	32	29	39
Right middle gyrus, BA10	3.24	0.001	11	38	45	16
Left superior occipital gyrus, BA19	3.42	<0.001	41	−42	−72	28
Left precuneus, BA7	3.20	0.001	32	0	−63	60
Left parietal lobe, BA7	3.16	0.001	32	−4	−62	70
naMCI × aMCI^b
Right middle frontal gyrus, BA46	3.33	<0.001	19	51	29	26

^aResults at the peak voxel level (global analysis, analysis of variance and post-hoc nonpaired t test). SPM8 software from Wellcome Department of Cognitive Neurology (Functional Imaging Laboratory, London, UK)
^bUncorrected for multiple comparisons
aMCI amnestic mild cognitive impairment, BA Broadmann area, CG control group, naMCI nonamnestic mild cognitive impairment, rBGM regional brain glucose metabolism

ISSN: 1758-9193