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Figure 1 | Alzheimer's Research & Therapy

Figure 1

From: Comparing recruitment, retention, and safety reporting among geographic regions in multinational Alzheimer’s disease clinical trials

Figure 1

Time to discontinuation models. In time to early discontinuation models for each study program arm, Japan differed significantly from South America/Mexico in the IDENTITY active semagacestat arms (A), from Asia and Eastern Europe/Russia in the IDENTITY placebo arms (B), from North America in the EXPEDITION active solanezumab treatment arms (C), and from Eastern Europe/Russia for the EXPEDITION placebo arms (D) (P < 0.01 for all comparisons by log-rank test). Eastern Europe/Russia differed from Australia/South Africa, North America, and Western Europe/Israel in the IDENTITY placebo arms (P < 0.01 by log-rank test). South America/Mexico differed from Western Europe/Israel in the IDENTITY active semagacestat arms (P < 0.01 by log-rank test).

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