From: Peripheral and central effects of γ-secretase inhibition by semagacestat in Alzheimer’s disease
Semagacestat AUC | Change in plasma Aβ40 | AUC adjusted for Aβ40 | Aβ40 adjusted for AUC | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
r | n | P | r | n | P | r | n | P | r | n | P | |
Change in uric acid at week 76 | −0.151 | 320 | 0.007 | 0.011 | 263 | 0.857 | −0.149 | 260 | 0.016 | 0.071 | 260 | 0.255 |
Change in albumin at week 76 | −0.14 | 320 | 0.012 | −0.131 | 263 | 0.033 | −0.037 | 260 | 0.548 | −0.107 | 260 | 0.084 |
Gastrointestinal symptoms | 0.015 | 943 | 0.654 | 0.099 | 507 | 0.025 | −0.004 | 501 | 0.933 | 0.094 | 501 | 0.034 |
Skin disorder incidence | 0.016 | 943 | 0.627 | 0.083 | 507 | 0.062 | −0.048 | 501 | 0.279 | 0.096 | 501 | 0.031 |
Skin cancer incidence | −0.012 | 943 | 0.71 | 0.075 | 507 | 0.091 | −0.039 | 501 | 0.389 | 0.084 | 501 | 0.059 |
Infection incidence | 0.136 | 943 | <0.001 | 0.072 | 507 | 0.101 | 0.068 | 501 | 0.129 | 0.042 | 501 | 0.344 |
Annualized change in FDG SUVR | 0.22 | 74 | 0.06 | <0.001 | 48 | 0.998 | 0.357 | 48 | 0.010 | −0.134 | 48 | 0.364 |
Annualized change in ventricular volume | 0.003 | 139 | 0.97 | 0.242 | 91 | 0.021 | −0.109 | 91 | 0.302 | 0.264 | 91 | 0.010 |
Annualized change in right hippocampal volume | −0.064 | 130 | 0.472 | −0.264 | 86 | 0.014 | −0.039 | 86 | 0.719 | −0.222 | 86 | 0.038 |
Annualized change in left hippocampal volume | −0.109 | 130 | 0.216 | −0.036 | 86 | 0.74 | −0.167 | 86 | 0.123 | 0.043 | 86 | 0.697 |
Annualized change in AV45 SUVR | 0.133 | 40 | 0.414 | 0.316 | 27 | 0.109 | −0.079 | 27 | 0.697 | 0.324 | 27 | 0.093 |
Annualized change in ADASCog11 | −0.012 | 938 | 0.707 | 0.037 | 505 | 0.403 | −0.080 | 499 | 0.074 | 0.060 | 499 | 0.177 |
Annualized change in MMSE | 0.038 | 618 | 0.351 | −0.019 | 496 | 0.678 | 0.057 | 490 | 0.211 | −0.037 | 490 | 0.414 |
Annualized change in p-tau | 0.02 | 37 | 0.909 | −0.124 | 33 | 0.491 | 0.101 | 33 | 0.578 | −0.154 | 33 | 0.395 |
Annualized change in total tau | 0.07 | 35 | 0.691 | 0.003 | 31 | 0.986 | −0.017 | 31 | 0.930 | 0.010 | 31 | 0.957 |
Annualized change in CSF Aβ42 | −0.13 | 37 | 0.443 | 0.152 | 33 | 0.399 | −0.103 | 33 | 0.571 | 0.179 | 33 | 0.318 |