Peripheral and central effects of γ-secretase inhibition by semagacestat in Alzheimer’s disease

Table 2 Correlations between peripheral biomarkers ^a

	AUC	Plasma Aβ40	Uric acid	Albumin	EOS	GI	Skin	Skin cancer	Infection
AUC	1; 0	−0.36; 0.001	−0.15; 0.007	−0.14; 0.01	0.18; 0.001	0.02; 0.65	−0.02; 0.63	−0.01; 0.81	0.14; 0.001
Plasma Aβ40		1; 0	−0.01; 0.86	0.131; 0.03	−0.19; 0.002	−0.10; 0.03	−0.08; 0.06	−0.08; 0.09	−0.07; 0.11
Uric acid			1; 0	0.08; 0.13	−0.23; 0.001	0.03; 0.60	−0.12; 0.04	−0.08; 0.13	−0.11; 0.04
Albumin				1; 0	−0.22; 0.001	0.05; 0.42	0.02; 0.72	0.02; 0.68	−0.15; 0.006
EOS					1; 0	−0.01; 0.85	0.04; 0.50	0.11; 0.06	0.08; 0.17
GI						1; 0	0.11; 0.001	0.05; 0.16	0.17; 0.001
Skin							1; 0	0.14; 0.001	0.13; 0.001
Skin cancer								1; 0	0.123; 0.001
Infection									1; 0

^aAβ40, Amyloid-β peptide 40; AUC, Area under the concentration curve; EOS, Eosinophils; GI, Gastrointestinal. Data are Spearman’s correlation coefficients and P-values (r; P).

ISSN: 1758-9193