Apolipoprotein E-dependent load of white matter hyperintensities in Alzheimer’s disease: a voxel-based lesion mapping study

Table 3 Effects on total white matter hyperintensity volume (analysis of variance model with APOE ε4 status (non-carrier versus carrier as factor of interest) in subjects with white matter hyperintensity ^a ≤10 cm ³

	Model 1 (n = 183)		Model 2 (n = 129)
	f (1, 169)	P -value	f (1, 107)	P -value
APOE ε4 carrier status	8.9	0.01	9.1	0.01
Age	39.7	0.01	42.6	0.01
Sex	1.5	0.22	2.4	0.13
Education	0.69	0.41	0.03	0.86
Disease classification	1.4	0.24	1.7	0.20
Total intracranial volume	4.9	0.03	9.2	0.01
Duration of disease			0.07	0.80
MMSE score^b			0.004	0.95
Systolic blood pressure			0.16	0.69
Diastolic blood pressure			10.4	0.01
Antihypertensive medication			0.40	0.53
Coronary heart disease			0.004	0.95
Cholesterol medication			0.49	0.49
Diabetes medication			0.006	0.94

^aResults for site covariates are not reported. ^bMMSE, Mini Mental State Examination.

ISSN: 1758-9193