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Table 1 Characteristics of patients with probable Alzheimer’s disease according to new diagnostic guidelines a

From: Apolipoprotein E-dependent load of white matter hyperintensities in Alzheimer’s disease: a voxel-based lesion mapping study

 

APOE ε4 carriers (n = 120)

APOE ε4 non-carriers (n = 63)

Group comparison P -values b

Total number of patients

N = 183

 

Age (yr)

70.4 ± 6.4

70.4 ± 8.7

0.97

Age at onset (yr)

67.6 ± 7.2

66.8 ± 12.2

0.96

Duration of disease (mo)

31.3 ± 24.7

30.5 ± 25.4

0.84

Males/females, n (ratio)

57/63 (1:1.1)

28/35 (1:1.3)

0.70

Education (yr)

9.1 ± 1.8

9.4 ± 2.2

0.30

Systolic blood pressure (mmHg)

139.3 ± 17.0c

141.1 ± 16.9d

0.54

Systolic blood pressure ≥140 mmHg (yes/no)

57/42 (1.4 : 1)

32/23 (1.4 : 1)

0.95

Diastolic blood pressure (mmHg)

81.6 ± 8.7c

83.8 ± 7.9d

0.14

Diastolic blood pressure ≥90 mmHg (yes/no)

33/66 (1:2)

20/35 (1:1.8)

0.78

Antihypertensive medication (yes/no)

31/87 (1 : 2.8)e

20/39 (1 : 2)f

0.18

Coronary heart disease (yes/no)

7/111 (1 : 15.9)e

5/56 (1 : 9.3)g

0.57

Diabetes (yes/no)

16/102 (1 : 6.4)e

6/53 (1 : 8.8)f

0.45

Hypercholesterolemia (yes/no)

15/100 (1 : 6.7)h

7/47 (1 : 6.7)i

0.99

BMI

24.5 ± 3.9j

24.2 ± 4.9i

0.85

CDR SOB

4.3 ± 1.4

4.3 ± 1.6

0.92

MMSE (score)

23.8 ± 3.2k

24.5 ± 2.9

0.51

Delayed verbal recall (score)

2.1 ± 2.0j

2.8 ± 2.2

0.02

Verbal learning

12.1 ± 4.3j

12.4 ± 4.4

0.87

Trail Making Test A (s)

96.6 ± 57.0l

96.1 ± 52.3

0.60

Constructive -apraxia

9.0 ± 2.3k

9.0 ± 1.8

0.59

Boston Naming Test

12.6 ± 2.4k

12.8 ± 2.4

0.80

  1. a APOE, Apolipoprotein E; BMI, Body mass index; CDR SOB, Clinical Dementia Rating Sum of Boxes; MMSE, Mini Mental State Examination. Data are presented as mean ± SD or ratio. b P-values are based on Student’s t-test. Available data: cn = 99, dn = 55, en = 118, fn = 59, gn = 61, hn = 115, in = 54, jn = 99, kn = 119, ln = 116.