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Table 2 Baseline characteristics of pooled populations

From: Cumulative, additive benefits of memantine-donepezil combination over component monotherapies in moderate to severe Alzheimer’s dementia: a pooled area under the curve analysis

Parameter

Statistic/Category

PBO

MEM

PBO-DON

MEM-DON

Age, years

number

281

289

418

429

Range

51 to 97

50 to 95

50 to 97

50 to 95

Mean ± SD

77.3 ± 7.8

77.2 ± 8.3

76.1 ± 8.3

75.8 ± 8.2

P-value

0.0378b

Sexa

Men

91 (32)

79 (27)

130 (31)

144 (34)

Women

190 (68)

210 (73)

288 (69)

285 (66)

P-value

0.3482c

Racea

Non-white

40 (14)

47 (16)

24 (6)

24 (6)

White

241 (86)

242 (84)

394 (94)

405 (94)

P-value

<0.0001b

Weight, kg

Number

281

285

418

429

Range

39 to 106

31 to 110

39 to 128

36 to 113

Mean ± SD

65.9 ± 13.3

64.4 ± 13.0

65.4 ± 13.9

67.9 ± 14.0

P-value

0.0049b

MMSE score

Number

281

289

418

429

Range

1 to 16

2 to 15

3 to 15

3 to 16

Mean ± SD

9.3 ± 3.5

9.0 ± 3.4

10.6 ± 2.9

10.6 ± 3.0

P-value

<0.0001b

  1. aData are presented as number (%); banalysis of variance (ANOVA); cChi-squared test.
  2. DON, donepezil; MEM, memantine; MMSE, Mini Mental State Exam; PBO, placebo; SD, standard deviation.