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Figure 1 | Alzheimer's Research & Therapy

Figure 1

From: Quantitative neuropathological assessment to investigate cerebral multi-morbidity

Figure 1

Digital quantification of tau pathologies. (A) Analyses are performed on a paired helical filament-1 immunostained section. (B) After the crafted Genie neurofibrillary tangle/neuritic plaque (NFT/NP) algorithm was used to isolate the NFTs, the NFT density (NFTs/mm2) is determined by a modified nuclear algorithm, with NFT pseudo-colored yellow. (C) In a similar manner, the NP burden is calculated by first using the same crafted Genie algorithm to isolate the NPs, here pseudocolored orange. (D) An overall tau burden is also calculated: red: positive immunohistochemical (IHC) staining; blue: negative IHC staining. Scale bar, 25 μm. (E) A sample of the data that are provided in each pathology report from the University of Kentucky for a quantitative description of Alzheimer’s disease (AD) pathology. ADNC, Alzheimer’s disease neuropathologic change; CA1, hippocampus sector CA1; CERAD, Consortium to Establish a Registry for Alzheimer’s Disease; Inf, inferior; SMTG, superior and middle temporal gyri.

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