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Figure 1 | Alzheimer’s Research & Therapy

Figure 1

From: Prevalence of mixed pathologies in the aging brain

Figure 1

Frequencies of different brain pathologies reported in the studies discussed in the present review. Box-plot representation of brain pathology frequencies (A) for all study subjects pooled together and (B) separately for individuals with or without (that is, with no) cognitive impairment (CI). AD defined as the frequency of AD-related pathology starting from Braak and Braak stages III to VI or National Institute on Aging–Reagan criteria intermediate or high likelihood, ignoring other pathologies. Mixed pathologies defined as AD plus any other pathology (see also Table–2). AD, Alzheimer’s disease; aSyn, α-synuclein; HS, hippocampal sclerosis; n, number of studies that report any values; TDP, TDP-43 proteinopathy; Vasc, vascular pathology.

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