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Figure 3 | Alzheimer's Research & Therapy

Figure 3

From: β-site amyloid precursor protein-cleaving enzyme 1(BACE1) inhibitor treatment induces Aβ5-X peptides through alternative amyloid precursor protein cleavage

Figure 3

The relative mass spectrometric change from baseline and ELISA-derived concentrations in response to a single dose of 30 mg or 90 mg of the BACE inhibitor LY2811376. (A) Mass spectrometric change in the CSF Aβ1-34 time course after LY2811376 treatment and (B) mass spectrometric change in the CSF Aβ5-40 time course after LY2811376 treatment. (C) ELISA-derived concentrations of the CSF Aβ5-40 time course after LY2811376 treatment and (D) ELISA-derived concentrations of the CSF Aβ5-X time course after LY2811376 treatment. Open circles represent placebo, grey squares represent treatment with 30 mg LY2811376 and closed triangles represent treatment with 90 mg LY2811376. Data are presented as mean ± SD and n =6 for both graphs. Aβ, β-amyloid; BACE, β-site APP-cleaving enzyme; CSF, cerebrospinal fluid; n, number; SD, standard deviation.

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