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Figure 2 | Alzheimer's Research & Therapy

Figure 2

From: β-site amyloid precursor protein-cleaving enzyme 1(BACE1) inhibitor treatment induces Aβ5-X peptides through alternative amyloid precursor protein cleavage

Figure 2

Mass spectra displaying multiple Aβ species recovered from human CSF specimens by immunoprecipitation with the anti-Aβ antibodies 6E10 and 4G8. (A) Pre-treatment, (B) 12, (C) 24, and (D) 36 hours post treatment with 90 mg of LY2811376. The right-hand panels are magnified spectra displaying the increase in Aβ5-40 and decrease in Aβ1-34 in response to treatment. Aβ, β-amyloid; CSF, cerebrospinal fluid.

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