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Figure 1 | Alzheimer's Research & Therapy

Figure 1

From: β-site amyloid precursor protein-cleaving enzyme 1(BACE1) inhibitor treatment induces Aβ5-X peptides through alternative amyloid precursor protein cleavage

Figure 1

Mass spectra displaying the effect of treatment on multiple Aβ species in cell media. (A) DMSO (vehicle), (B) 1.25 μM of the BACE1-inhibitor LY2811376, (C) 2.5 μM of the BACE1-inhibitor LY2811376, (D) 1.25 μM of the BACE-inhibitor BACE IV and (E) 2.5 μM of the BACE-inhibitor BACE IV in media from SH-SY5Y cells. *Represent unidentified peaks. Aβ, β-amyloid; BACE, β-site APP-cleaving enzyme; DMSO, dimethyl sulfoide.

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