Analyzing the impact of 23 mg/day donepezil on language dysfunction in moderate to severe Alzheimer's disease

Table 3 Correlations between SIB-L and SIB[lang] scores and scores on the ADCS-ADL-sev (total, basic and instrumental), CIBIS/CIBIC-plus and MMSE (full ITT population)^a

	SIB-L			SIB[lang]
AD scales	Baseline	Week 24	Change from baseline	Baseline	Week 24	Change from baseline
ADCS-ADL-sev total
Baseline	0.5268		0.1497	0.5250		0.1418
Week 24		0.5820			0.5777
Change from baseline			0.2837			0.2912
ADCS-ADL-sev basic
Baseline	0.5214		0.1124	0.5193		0.1036
Week 24		0.5669			0.5621
Change from baseline			0.2643			0.2695
ADCS-ADL-sev instrumental
Baseline	0.4745		0.1546	0.4730		0.1481
Week 24		0.5400			0.5365
Change from baseline			0.2369			0.2441
CIBIS-plus/CIBIC-plus
Baseline (CIBIS-plus)	-0.5100		-0.1722	-0.5117		-0.1821
Week 24 (CIBIC-plus)		-0.1918			-0.1891
Change from baseline (CIBIC-plus)			-0.3484			-0.3493
MMSE
Baseline	0.7208		0.2205	0.7183		0.2359
Week 24		0.7375			0.7394
Change from baseline			0.3618			0.3517

^aSIB-L = Severe Impairment Battery-Language scale; SIB[lang] = 21-item Severe Impairment Battery-derived language scale; ADCS-ADL-sev = Alzheimer's Disease Cooperative Study-Activities of Daily Living inventory, severe version; CIBIS-plus = Clinician's Interview-Based Impression of Severity-plus caregiver input; CIBIC-plus = Clinician's Interview-Based Impression of Change-plus caregiver input; MMSE = Mini-Mental State Examination; ITT = intention to treat; n values for individual correlation coefficients ranged from 1,363 to 1,371. All correlations were statistically significant (P ≤ 0.0001).

ISSN: 1758-9193