Table 4 Association of senile plaque coverage with APOE, CLU, CR1 and PICALM genotypes
From: CLU, CR1 and PICALM genes associate with Alzheimer's-related senile plaques
Sparse SP | Moderate SP | Frequent SP | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Valid N | No SP | Sparse SP | OR (95% CI) | P-value | Moderate SP | OR (95% CI) | P-value | Frequent SP | OR (95% CI) | P-value | |
APOEε4-1 | 378 | 281 (74.3) | 51 (13.5) | - | - | 29 (7.7) | - | - | 17 (4.5) | - | - |
APOEε4+ | 174 | 89 (51.1) | 39 (22.4) | 2.86 (1.73 to 4.74) | <0.0001* | 32 (18.4) | 5.32 (2.81 to 10.06) | <0.0001* | 14 (8.0) | 3.97 (1.76 to 8.94) | 0.001* |
CLU TT2 | 329 | 227 (69.0) | 48 (14.6) | - | - | 33 (10.0) | - | - | 21 (6.4) | - | - |
CLU C+ | 192 | 123 (64.1) | 37 (19.3) | 1.26 (0.76 to 2.09) | 0.378 | 23 (12.0) | 1.06 (0.55 to 2.03) | 0.873 | 9 (4.7) | 0.68 (0.29 to 1.63) | 0.391 |
CR1 AA2 | 182 | 125 (68.7) | 22 (12.1) | - | - | 21 (11.5) | - | - | 14 (7.7) | - | - |
CR1 C+ | 355 | 234 (65.9) | 65 (18.3) | 1.48 (0.85 to 2.58) | 0.167 | 38 (10.7) | 0.92 (0.48 to 1.78) | 0.807 | 18 (5.1) | 0.62 (0.28 to 1.38) | 0.242 |
PICALM CC2 | 217 | 136 (62.7) | 33 (15.2) | - | - | 32 (14.7) | - | - | 16 (7.4) | - | - |
PICALM T+ | 319 | 222 (69.6) | 54 (16.9) | 0.97 (0.58 to 1.60) | 0.898 | 27 (8.5) | 0.43 (0.23 to 0.82) | 0.010* | 16 (5.0) | 0.58 (0.26 to 1.26) | 0.169 |