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Table 3 Association of senile plaque type with APOE, CLU, CR1 and PICALM genotypes

From: CLU, CR1 and PICALM genes associate with Alzheimer's-related senile plaques

  

SP

Diffuse

Primitive

Classic

Burnt out

 

Valid N

SP

OR (95% CI)

P-value

Diffuse

OR (95% CI)

P-value

Primitive

OR (95% CI)

P-value

Classic

OR (95% CI)

P-value

Burnt out

OR (95% CI)

P-value

APOEε4-1

388

88 (22.7)

-

-

12 (3.1)

-

-

19 (4.9)

-

-

44 (11.3)

-

-

13 (3.4)

-

-

APOEε4+

174

74 (42.5)

3.2 (2.05 to 4.90)

<0.0001*

9 (5.2)

2.4 (0.97 to 5.86)

0.059

16 (9.2)

2.8 (1.37 to 5.74)

0.005*

37 (21.3)

3.2 (1.83 to 5.48)

<0.0001*

12 (6.9)

3.8 (1.56 to 9.01)

0.003*

CLU TT2

336

89 (26.5)

-

-

13 (3.9)

-

-

22 (6.5)

-

-

48 (14.3)

-

-

6 (1.8)

-

-

CLU C+

194

60 (30.9)

1.1 (0.73 to 1.76)

0.570

6 (3.1)

0.79 (0.29 to 2.14)

0.641

11 (5.7)

0.9 (0.39 to 1.84)

0.680

27 (13.9)

0.99 (0.56 to 1.77)

0.988

16 (8.2)

4.4 (1.61 to 12.2)

0.004*

CR1 AA2

186

56 (30.1)

-

-

8 (4.3)

-

-

9 (4.8)

-

-

28 (15.1)

-

-

11 (5.9)

-

-

CR1 C+

361

102 (28.3)

0.9 (0.62 to 1.54)

0.924

12 (3.3)

0.71 (0.28 to 1.80)

0.475

24 (6.6)

1.2 (0.55 to 2.77)

0.611

53 (14.7)

0.85 (0.48 to 1.49)

0.572

13 (3.6)

0.57 (0.24 to 1.40)

0.221

PICALM CC2

219

71 (32.4)

-

-

7 (3.2)

-

-

19 (8.7)

-

-

37 (16.9)

-

-

8 (3.7)

-

-

PICALM T+

327

87 (26.6)

0.6 (0.41 to 0.95)

0.028*

12 (3.7)

1.09 (0.42 to 2.84)

0.864

16 (4.9)

0.5 (0.26 to 1.09)

0.086

42 (12.8)

0.73 (0.42 to 1.25)

0.253

17 (5.2)

1.36 (0.55 to 3.39)

0.508

  1. Abbreviations: APOE , Apolipoprotein E; CI, confidence intervals; CLU , Clusterin; CR1, complement component (3b/4b) receptor 1; N, number of cases; OR, odds ratio; PICALM, phosphatidylinositol-binding clathrin assembly protein; SP, senile plaques; No SP was the reference group. Numbers in brackets are percentages, unless otherwise stated. In some cases it was impossible to obtain all variables due to technical difficulties and sample damage.
  2. * Denotes statistically significant values.
  3. 1 Denotes reference group used for statistical analyses. Age was used as a covariate.
  4. 2 Denotes most common homozygous genotype and used as the reference group for statistical analyses. APOEε4 carriership and age were used as covariates.