Table 3 Amyloid imaging and prediction of conversion to Alzheimer's disease
From: Amyloid imaging and memory change for prediction of cognitive impairment
Study | Year | Radiotracer | Samplea | Number of subjectsa | Mean age (SD) | Method | Findings |
|---|---|---|---|---|---|---|---|
Okello et al. [24] | 2009 | PiB | MCI | 31 | 69.4 (7.9) | SUVR | 82% PiB-positive MCI convert to AD compared to 7% of PiB-negative MCI 47% PiB-positive MCI who convert to AD within 1 year have higher PiB in anterior cingulate and frontal cortex (P < 0.05), APOE ε4 is associated with faster conversion rates in PiB-positive MCI (P < 0.05) |
Wolk et al. [25] | 2009 | PiB | MCI | 26 (23 with follow-up) | 70.2 (8.8) | DVR | 38% PiB-positive MCI but no PiB- convert to AD over 22 months |
Morris et al. [45] | 2009 | PiB | CN | 159 | 71.5 (8.6) | BP | Higher PiB retention predicts progression from CDR 0 to MCI (hazard ratio = 2.74) and AD (hazard ratio = 4.85) over mean 2.4 years |
Koivunen et al. [44] | 2008 | PiB | aMCI | 15 | 71.1 (7.2) | SUVR, DVR | Elevated PiB in six converters in posterior cingulate and frontal cortex as well as elevated neocortical score |
Forsberg et al. [23] | 2008 | PiB | MCI | 21 | 63.3 (7.8) | SUVR | Higher PiB retention in frontal, parietal, and temporal cortices (P < 0.01) in MCI converters than CN individuals Higher PiB retention in posterior cingulate gyrus in MCI converters than MCI nonconverters (P < 0.01) No difference in PiB retention between MCI converters and AD |
Small et al. [20] | 2006 | [18F]FDDNP | AD, MCI, CN | 4 MCI, 8 CN | NA for this subset | DVR | Three disease progressors had increases in [18F]FDDNP between 5.5% to 11.2% compared to ≤3% in nine non-progressors |