Table 2 Associations between β-amyloid burden and cognition in cognitively normal individuals

Cross-sectional measures of concurrent β-amyloid load and cognition

Rowe et al. [7]

No association with long delay verbal recall (CVLT) No difference in long delay verbal recall between those with high versus low PiB binding

Rentz et al. [33]

No main effect of precuneus PiB on cognitive function Higher precuneus PiB associated with lower cued (but not free recall) and canonical variate score in CN individuals with low but not high cognitive reserve measured by AMNART

Storandt et al. [42]

No association with global, verbal, spatial, or working memory composites or individual cognitive measures

Braskie et al. [39]

Higher [¹⁸F]FDDNP in right frontal and some parietal areas associated with lower composite cognitive score

Mormino et al. [41]

Higher PiB associated with lower episodic memory composite score (P < 0.01)

Mormino et al. [41]

No associations with episodic memory composite score

Rowe et al. [28]

No difference in cognitive performance between PiB-positive and PiB-negative

Pike et al. [35]

Higher PiB associated with lower episodic memory composite score (r = -0.38, P < 0.05) PiB-positive compared with PiB-negative had lower episodic memory composite score (P < 0.05)

Cross-sectional measures of β-amyloid load and longitudinal measures of cognition

Resnick et al. [6]

Higher PiB associated with greater decline in immediate and delayed verbal recall and MMSE (all P ≤ 0.01) but not visual memory

Associations most pronounced for frontal and lateral temporal cortex, as well as putamen

Storandt et al. [42]

Higher PiB associated with greater decline in working memory and visuospatial ability

Villemagne et al. [43]

Higher PiB associated with greater decline in word-list recall (r = -0.78) in decliners only