From: Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease
Treatment (mg/kg/dose) | Duodenum | Ileum | ||
---|---|---|---|---|
 | # animals affected | Mean severity score | # animals affected | Mean severity score |
Vehicle | 0 | NA | 0 | NA |
5 mg/kg LY411575 | 4* | 2 | 5 | 3 |
15 mg/kg ELN475516 | 0 | NA | 0 | NA |
30 mg/kg ELN475516 | 0 | NA | 4 | 0.5 |
100 mg/kg ELN475516 | 0 | NA | 2 | 1.25 |
300 mg/kg ELN475516 | 0 | NA | 0 | NA |
600 mg/kg ELN475516 | 0 | NA | 2 | 0.5 |
1,000 mg/kg ELN475516 | 0 | NA | 1 | 0.5 |