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Figure 6 | Alzheimer's Research & Therapy

Figure 6

From: Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease

Figure 6

Time course of brain Aβ reduction in wildtype FVB mice after treatment with a single dose of ELN475516. Female FVB mice were treated orally with a single dose of ELN475516 (30, 100 or 300 mg/kg, n = 5/dose group) or vehicle and sacrificed at 1, 3, 6, 10, 14 and 24 hours post dose. (a) Cortical Aβx-40 levels, estimated by ELISA from guanidine extracted brain homogenates. (b) ELN475516 levels in plasma and brain estimated by LC/MS/MS. (c) ELN475516 plasma and brain exposure over 24 hours (AUC0-24).

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