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Figure 5 | Alzheimer's Research & Therapy

Figure 5

From: Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease

Figure 5

Reduction of brain Aβ and thymic Hes-1 in wild-type FVB mice after treatment with gamma-secretase inhibitor. Female FVB mice were treated orally with a single dose of ELN475516 (30, 100 or 300 mg/kg), LY411575 (10 mg/kg) or vehicle and sacrificed at three hours post dose. (a) Cortical Aβx-40 levels, estimated by ELISA from guanidine extracted brain homogenates. (b) Thymic Hes-1 mRNA levels, estimated by TaqMan RT-PCR. Statistical significance between treatment groups and vehicle was determined by ANOVA and Dunnett's test. *** P < 0.001, * P < 0.05

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