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Figure 4 | Alzheimer's Research & Therapy

Figure 4

From: Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease

Figure 4

Acute reduction of brain Aβ by ELN318463 in PDAPP (a) and FVB mice (b). The mice were dosed orally with vehicle, or ELN318463 at 30 mg/kg or 100 mg/kg and sacrificed 3 h post treatment. Brain Aβ1-x in PDAPP (a), or Aβx-40 in FVB (b) was quantified by ELISA following extraction in guanidine buffer as described in methods. ** denotes P < 0.01, *** denotes P < 0.001 by Mann-Whitney in A, and two-tailed Students t-test in (b).

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