Figure 5
From: Cerebral amyloid angiopathy in the aetiology and immunotherapy of Alzheimer disease
Impaired lymphatic drainage of the brain in the pathogenesis of cerebral amyloid angiopathy (CAA) and Alzheimer disease (AD). The schema outlines a working hypothesis for the failure of perivascular lymphatic drainage of the brain with age and how such a failure contributes to the pathogenesis of CAA and AD. Aβ, amyloid-beta; ECS, extracellular spaces; ISF, interstitial fluid; NFT, neurofibrillary tangle.