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Figure 1 | Alzheimers Res Ther

Figure 1

From: Proteinopathy-induced neuronal senescence: a hypothesis for brain failure in Alzheimer's and other neurodegenerative diseases

Figure 1

Proteinopathy-induced neuronal senescence. A schematic of proteinopathy-induced neuronal senescence depicts protein misfolding and aggregation as a trigger for a self-reinforcing cycle of pro-inflammatory signals and senescence. As a critical mass of neurons acquire a physiologically senescent phenotype overt neurodegeneration and failures in the brain's cognitive and regulatory functions become clinically apparent.

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Alzheimer's Research & Therapy

ISSN: 1758-9193