Study | Subjects | Associations |
---|---|---|
Archer et al., 2006 [70] | 9 AD | Positive correlation between rates of whole-brain atrophy and regional PIB uptake |
Jack et al., 2008 [69] | 20 CN, 17 MCI, 8 AD | aProportional odds to separate all groups: PIB: 0.75; MRI: 0.84; MRI + PIB: 0.86. Global PIB and MRI were correlated with each other as well as with clinical measures. |
Jack et al., 2009 [1] | 21 CN, 32 MCI, 8 AD | Longitudinal annual change was observed only in MRI and not in PIB. Change in MRI was associated with change in cognitive measures. |
Mormino et al., 2009 [2] | 37 CN, 39 PIB + MCI | PIB and MRI were correlated with each other as well as with episodic memory. |
Scheinin et al., 2009 [71] | 13 CN, 14 AD | During 2 years, only longitudinal MRI change was observed but not in PIB. |
Strorandt et al., 2009 [66] | 135 CN | PIB was associated with cross-sectional brain atrophy and longitudinal cognitive decline. |
Bourgeat et al., 2010 [68] | 92 CN, 32 MCI, 35 AD | In CN, PIB retention in the inferior temporal region and hippocampal volume were strongly correlated. |
Chetalat et al., 2010 [67] | 94 CN (49 subjective cognitive impairment), 34 MCI, 35 AD | Global atrophy and regional atrophy were strongly related to PIB load in CN subjects with subjective cognitive impairment but not MCI and AD. |
Driscoll et al., 2010 [65] | 57 CN | In CN, current PIB load was not related to longitudinal MRI changes in the preceding years. |