Study | Subjects | Diagnostic measures | Associations |
---|---|---|---|
Yamaguchi et al., 1997 [78] | 13 AD, 13 CN | Â | Hippocampal volume and mean cortical cerebral glucose metabolic rates of the temporal lobe, temporo-parieto-occipital, and frontal regions were correlated. |
De Santi et al., 2001 [59] | 11 CN, 15 MCI, 12 AD | Accuracy for separation of MCI and CN: MRI: 73%; FDG: 73% to 85% AD and CN: MRI: 83%; FDG: 100% | FDG and MRI measures in hippocampal formation best characterize MCI, and additional neocortical damage best characterizes AD. |
Ishii et al., 2005 [79] | 30 CN, 30 very mild AD | Â | VBM: decrease in MRI in medial temporal lobes and decrease in FDG in posterior cingulate and parietal lobule |
Kawachi et al., 2006 [60] | 60 CN, 30 very mild AD, 32 mild AD | Accuracy for separating very mild AD and CN: FDG: 89%; MRI: 83%; MRI + FDG: 94% | VBM: decrease in MRI in bilateral amygdala/hippocampus complex and decrease in FDG in bilateral posterior cingulate and parietotemporal area |
Mosconi et al., 2006 [58] | 7 CN, 7 asymptomatic at-risk FAD | Accuracy for separation of both groups: MRI: 43% to 86%; FDG: 50% to 100% | FDG showed significant decrease but little sMRI change in asymptomatic subjects. |
Ishii et al., 2007 [62] | 20 very mild AD, 20 DLB, 20 CN | Accuracy for separation of DLB and AD: MRI: 62% to 80%; FDG: 66% to 87% | Both MRI and FDG had a hippocampal decrease due to AD. |
Matsunari et al., 2007 [61] | Group 1: 40 CN, 27 AD Group 2 (early- and late-onset): 50 CN, 34 AD | Accuracy for different comparisons: MRI: 74% to 92%; FDG: 92% to 100% | VBM: decrease in MRI in hippocampal complex and decrease in FDG in posterior cingulate and parietotemporal area |
Samuraki et al., 2007 [80] | 73 CN, 39 AD | Â | VBM: FDG uptake was preserved in the medial temporal lobe before as well as after correction with MRI. |
Chetelat et al., 2008 [81] | 15 CN, 18 mild AD | Â | FDG hypometabolism exceeds MRI atrophy in the posterior cingulate-precuneus, orbitofrontal, inferior temporo-parietal, parahippocampal, angular, and fusiform areas. Similar degrees of atrophy and hypometabolism were observed in the hippocampus. |
Hinrichs et al., 2009 [63] | CN and AD subjects from ADNI: MRI: 183, FDG: 149 | AUROC for discrimination of AD and CN: MRI: 0.88; FDG: 0.87 | Â |
Walhovd et al., 2009 [82] | 22 CN, 44 MCI | Â | MRI predicted diagnostic groups for most regions of interest, but PET did not, except a trend for the precuneus metabolism. |
Yuan et al., 2009 [30] | Meta-analysis of 24 MCI studies (1112 subjects) | Odds ratio of predicting MCI conversion to AD: MRI: 10.6; FDG: 40.1 | FDG was better than MRI in predicting conversion of MCI to AD. |
Morbelli et al., 2010 [83] | 12 CN, 11 stable MCI, 9 MCI who progressed to AD | Â | MCI converters showed MRI changes in left parahippocampus and both thalami, whereas FDG showed MRI changes in left PCC, precuneus, superior parietal lobule. |
Walhovd et al., 2010 [44] | 42 CN, 73 MCI, 38 AD (ADNI) | Accuracy for baseline separation of AD and CN: MRI: 85%; FDG: 82.5% | MRI and FDG were largely overlapping in value for discrimination. |