From: A novel Aβ isoform pattern in CSF reflects γ-secretase inhibition in Alzheimer disease
Placebo | LY450139, 100 mg | LY450139, 140 mg | |
---|---|---|---|
Characteristic | ( n = 10) | ( n = 15) | ( n = 10) |
Demographics | |||
Age, mean (SD, years) | 69.1 (8.81) | 72.4 (8.13) | 68.8 (9.02) |
Female sex, number (%) | 5 (50) | 10 (66.6) | 4 (40) |
APOE e4 carriers, number (%) | 8 of 10 (80) | 11 of 13 (84.6) | 7 of 9 (77.8) |
Clinical scores, mean (SD) | |||
MMSE | 18.3 (4.0) | 22 (3.6) | 24.9 (1.4) |
ADCS-ADL | 61.9 (7.3) | 67.7 (8.4) | 70.6 (7.8) |
ADAS-Cog 11 | 26.9 (10.0) | 19.9 (6.3) | 17.9 (5.8) |