Solanezumab dosea | Mean CSF Aβ40, pg/mLb | Mean CSF Aβ42, pg/mLb |
---|
100 mg Q4W | 625 | 0.0 |
100 mg QW | 3,750 | 275 |
400 mg Q4W | 5,625 | 233 |
400 mg QW | 15,000 | 825 |
- aSolanezumab phase 2 MAD data [183]. bMean pg/mL levels of total bound and unbound Aβ40 and Aβ42 in cerebrospinal fluid (CSF) of treated patients, derived from Figures 3A and 3B reported by Farlow and colleagues [183]. Q4W, monthly dosing; QW, weekly dosing.