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Table 4 Comorbidity and medication risk factors for mortality (multivariate Cox regression analyses)

From: Cerebral inflammation is an underlying mechanism of early death in Alzheimer’s disease: a 13-year cause-specific multivariate mortality study

Risk factors (covariates)

Cause of death (dependent variable)

Significant variables

P value

HR (95% CI)

Comorbidities

Dementia

No significant variables

  
 

Dementia and related causes

Age

<0.001

1.31 (1.12–1.53)

 

All-cause mortality

Age

<0.001

1.30 (1.13–1.50)

  

Hypertension

0.041

1.34 (1.01–1.78)

Medications

Dementia

No significant variables

  
 

Dementia and related causes

Age

<0.001

1.30 (1.11–1.52)

 

All-cause mortality

Age

0.001

1.27 (1.10–1.47)

  

Cardiovascular drugs

0.024

1.38 (1.04–1.83)

  

Antipsychotics/sedatives

0.036

1.36 (1.02–1.81)

  1. Age was converted to a z-score for comparison with the continuous variables shown in Table 3. All comorbidities and medications with a prevalence ≥10% (Table 2), as well as age and sex, were entered into the Cox regression analyses. Comorbidities and medications were entered separately. HR, hazard ratio.