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Table 1 Characteristics (variables entered into the Cox Regression Analysis)

From: Cerebral inflammation is an underlying mechanism of early death in Alzheimer’s disease: a 13-year cause-specific multivariate mortality study

Variable

Mean ± SD (n = 247)

Time to death, n = 221 (years)

6.4 ± 3.0

Age (years)

75.2 ± 6.1

Sex (female)

69%

MMSE score (0 to 30 points)

21.3 ± 5.1

Temporal horn ratio (medial temporal atrophy)

0.040 ± 0.017

Evans ratio (frontal atrophy)

0.33 ± 0.038

Cella media index (central atrophy)

0.22 ± 0.040

CSF sVCAM-1 (neuroinflammatory pathology, μg/L)

11.7 ± 4.3

ARWMC (cerebrovascular pathology, 0 to 18 points)

3.2 ± 3.4

Albumin ratio (BBB integrity)

0.0075 ± 0.0032

CSF Tau (pg/ml)

619 ± 322

CSF P-tau (pg/ml)

76 ± 31

CSF Aβ42 (pg/ml)

410 ± 99

APOE ϵ4/ϵ4

22%

  1. Aβ, beta-amyloid; APOE, apolipoprotein E; ARWMC, Age-Related White Matter Changes scale; BBB, blood–brain barrier; CSF, cerebrospinal fluid; MMSE, the Mini-Mental State Examination; SD, standard deviation; sVCAM-1, soluble vascular cell adhesion molecule-1.