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Table 4 MAPT haplotype association results with brain MAPT gene expression levels

From: Association of MAPT haplotypes with Alzheimer’s disease risk and MAPT brain gene expression levels

Haplotype

Alleles

Brain region

Freq

ILMN_1710903

ILMN_2298727

ILMN_2310814

    

BETA

P

BETA

P

BETA

P

A (H2a)

AGGCGG

CER

0.212

-0.45

8.7E-33

-0.16

0.003

0.00

0.832

TCX

0.212

-0.49

1.1E-31

-0.20

0.001

0.02

0.308

B (H1b)

GGGCAA

CER

0.180

0.15

0.003

0.07

0.207

-0.01

0.691

TCX

0.180

0.13

0.026

0.13

0.058

0.01

0.630

C (H1c)

AAGTAG

CER

0.104

0.11

0.057

0.02

0.807

0.02

0.338

TCX

0.104

0.17

0.008

0.05

0.536

-0.02

0.309

D (H1d)

AAGCAA

CER

0.057

0.00

0.970

0.04

0.721

0.07

0.098

TCX

0.057

0.30

0.007

0.14

0.314

-0.02

0.646

E (H1e)

AGGCAA

CER

0.079

0.09

0.273

0.04

0.621

0.02

0.554

TCX

0.079

0.15

0.079

0.13

0.212

0.00

0.964

H

AGACAA

CER

0.025

0.05

0.748

-0.13

0.478

0.04

0.538

TCX

0.025

0.13

0.424

-0.05

0.803

-0.05

0.353

I

GAGCAA

CER

0.059

0.24

0.010

0.20

0.070

-0.04

0.322

TCX

0.059

0.07

0.422

-0.09

0.434

-0.01

0.766

L

AGACAG

CER

0.043

0.17

0.062

0.01

0.921

-0.02

0.634

TCX

0.043

-0.01

0.954

-0.33

0.009

0.01

0.841

M

GAGCAG

CER

0.028

0.26

0.043

0.01

0.936

0.01

0.829

TCX

0.028

0.16

0.298

-0.23

0.204

0.00

0.927

O

AAACAA

CER

0.037

0.19

0.104

0.00

0.985

-0.04

0.435

TCX

0.037

0.20

0.070

0.21

0.110

0.00

0.933

P

GGGTAG

CER

0.019

0.04

0.765

0.07

0.637

0.02

0.731

TCX

0.019

0.07

0.725

0.26

0.259

-0.03

0.613

T

AGATAG

CER

0.016

0.01

0.935

-0.24

0.212

-0.07

0.285

TCX

0.016

0.00

0.994

0.47

0.075

0.02

0.729

U

AAGCAG

CER

0.029

0.15

0.251

0.04

0.786

-0.14

0.008

TCX

0.029

0.35

0.008

0.25

0.112

-0.01

0.836

X

GAATAG

CER

0.025

0.10

0.406

0.19

0.168

0.06

0.248

TCX

0.025

-0.04

0.756

0.11

0.510

0.02

0.584

Y*

AAATAG

CER

0.022

-0.02

0.884

-0.13

0.458

-0.02

0.761

TCX

0.022

-0.03

0.841

-0.03

0.882

0.00

0.933

  

CER

Global p

3.0E-42

0.352

0.271

  

TCX

 

3.2E-36

0.004

0.999

  1. Haplotypes with frequencies > 1% are assessed with multivariable linear regression analysis. Alleles for the SNPs defining the haplotypes are given in the 5’ to 3’ order as follows: rs1467967, rs242557, rs3785883, rs2471738, rs8070723, rs7521. Haplotypes not previously observed are designated by an asterisk (*). CER = cerebellum, TCX = temporal cortex. Beta: Coefficient of association with the minor allele. P = p-value.
  2. Boldface values within the tables indicate significant or suggestive associations with a p-value <0.10.