A diagnostic scale for Alzheimer’s disease based on cerebrospinal fluid biomarker profiles

Table 2 AUCs

AUC	Paris-1	Paris-2	Lille-1	Lille-2	Mtp-1	Mtp-2	PLM-1	PLM-2	Mean
Aβ42	0.81	0.768	0.778	0.826	0.747	0.778	0.772	0.787	0.783
Tau	0.898	0.921	0.869	0.905	0.84	0.852	0.86	0.88	0.878
p-tau	0.911	0.913	0.87	0.917	0.842	0.91	0.875	0.912	0.894
IATI	0.902	0.895	0.858	0.917	0.827	0.877	0.855	0.896	0.878
Aβ42/tau	0.913	0.921	0.88	0.927	0.849	0.882	0.874	0.905	0.894
Aβ42/p-tau	0.923	0.92	0.875	0.92	0.86	0.924	0.884	0.924	0.904
Logi. reg.	0.926	0.928	0.892	0.936	0.869	0.933	0.896	0.932	0.914
Log. reg. scale	0.917	0.931	0.872	0.927	0.838	0.918	0.876	0.919	0.900
PLM scale	0.94	0.931	0.887	0.919	0.863	0.933	0.883	0.924	0.910

Area under the ROC for the individual biomarkers Aβ42, tau and p-tau, the IATI [21] and the ratios Aβ42/tau and Aβ42/p-tau. The values of the p(AD) obtained after logistic regression were also used to calculate the AUC. The logistic regression values were separated into four classes (0 to 3), which values were then used, just as for the PLM scale, to calculate the AUCs.

ISSN: 1758-9193