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Table 3 Association of cerebrospinal fluid complement biomarkers with baseline and longitudinal changes (biomarker × time) in cognitive scores: Alzheimer’s disease subjects

From: Low levels of cerebrospinal fluid complement 3 and factor H predict faster cognitive decline in mild cognitive impairment

Model

Predictor

ADAS-Cog

MMSE

Memory

Executive

β

P value

β

P value

β

P value

β

P value

C3

C3

−0.0095

1.0

−0.45

0.53

0.10

0.76

−0.061

1.0

C3 × time

−0.0089

1.0

−0.009

1.0

0.085

0.18

0.12

0.092

FH

FH

−0.017

1.0

−0.14

0.54

0.083

0.59

−0.057

1.0

FH × time

−0.0052

1.0

−0.0072

1.0

0.048

0.18

0.072

0.085

C3/FH

C3/FH

0.074

1.0

−1.25

0.51

−0.074

0.78

0.095

1.0

C3/FH × time

0.014

1.0

−0.0075

1.0

0.092

0.42

0.081

0.57

  1. Age, gender (male reference category), education, total tau/amyloid β peptide 1–42 ratio and apolipoprotein E epsilon 4 allele presence adjusted mixed-effects model. P values are corrected for multiple comparisons (Holms). ADAS-Cog, Alzheimer’s disease Assessment Scale – cognitive subscale; C3, complement 3; FH, factor H; MMSE, Mini-Mental State Examination.