| Controls | MCI subjects | AD subjects | P value |
---|---|---|---|---|
Number of participants | Â | Â | Â | Â |
 All | (n = 110) | (n = 187) | (n = 92) |  |
 Hgb ≤ 1,500 ng/ml | (n = 96) | (n = 163) | (n = 83) |  |
Age at baseline (years)a | Â | Â | Â | Â |
 All | 75.4 (5.2) | 74.0 (7.6) | 74.4 (7.7) | 0.24 |
 Hgb ≤ 1,500 ng/ml | 75.6 (5.0) | 74.5 (7.6) | 74.8 (7.9) | 0.42 |
Gender (% female)b | Â | Â | Â | Â |
 All | 49.1 | 33.2 | 43.8 | 0.019 |
 Hgb ≤ 1,500 ng/ml | 46.9 | 33.7 | 47.0 | 0.046 |
Education (years)a | Â | Â | Â | Â |
 All | 15.7 (2.8) | 15.8 (3.0) | 15.0 (3.2) | 0.15 |
 Hgb ≤ 1,500 ng/ml | 15.8 (2.8) | 15.8 (3.0) | 15.1 (3.2) | 0.19 |
MMSEa | Â | Â | Â | Â |
 All | 29.1 (1.0) | 27.0 (1.8) | 23.6 (1.9) | <0.0001 |
 Hgb ≤ 1,500 ng/ml | 29.1 (1.0) | 27.0 (1.8) | 23.7 (1.9) | <0.0001 |
ADAS-Coga | Â | Â | Â | Â |
 All | 9.7 (4.2) | 18.6 (6.7) | 28.5 (8.5) | <0.0001 |
 Hgb ≤ 1,500 ng/ml | 9.9 (4.1) | 18.7 (6.2) | 28.7 (7.7) | <0.0001 |
APOE ϵ4 presence (%)b |  |  |  |  |
 All | 24.5 | 54.0 | 70.7 | <0.0001 |
 Hgb ≤ 1,500 ng/ml | 24.0 | 55.2 | 68.7 | <0.0001 |
Hgb (ng/ml)c | Â | Â | Â | Â |
 All | 42.4 (0.0 to 418.8) | 24.9 (0.0 to 477.7) | 87.5 (0.0 to 338.4) | 0.79 |
 Hgb ≤ 1,500 ng/ml | 19.6 (0.0 to 171.0) | 0.64 (0.0 to 195.4) | 42.9 (0.0 to 226.1) | 0.40 |
Factor H (ng/ml)c | Â | Â | Â | Â |
 All | 1463.5 (1132.1 to 1954.1) | 1478.9 (1177.6 to 2005.5) | 1660.5 (1171.4 to 2274.1) | 0.26 |
 Hgb ≤ 1,500 ng/ml | 1445.4 (1128.8 to 1877.1) | 1452.0 (1176.3 to 1928.3) | 1507.9 (1145.3 to 2053.2) | 0.46 |
Complement 3 (ng/ml)c | Â | Â | Â | Â |
 All | 3331.4 (2595.5 to 4743.4) | 3696.0 (2658.9 to 4905.2) | 3894.6 (2567.6 to 5466.0) | 0.40 |
 Hgb ≤ 1,500 ng/ml | 3331.4 (2644.1 to 4819.2) | 3614.1 (2559.7 to 4597.7) | 3690.3 (2522.3 to 5328.1) | 0.73 |
Complement 3/factor Hc | Â | Â | Â | Â |
 All | 2.40 (1.80 to 2.91) | 2.42 (2.01 to 2.84) | 2.20 (1.95 to 2.64) | 0.31 |
 Hgb ≤ 1,500 ng/ml | 2.41 (1.86 to 2.95) | 2.41 (1.98 to 2.82) | 2.26 (1.95 to 2.78) | 0.55 |
Aβ1–42 (pg/ml)c |  |  |  |  |
 All | 220.0 (159.0 to 253.0) | 146.0 (128.0 to 202.0) | 136.0 (120.8 to 160.5) | <0.0001 |
 Hgb ≤ 1,500 ng/ml | 220.0 (159.5 to 252.5) | 146.0 (128.0 to 210.3) | 137.0 (121.5 to 161.5) | <0.0001 |
Total tau (pg/ml)c | Â | Â | Â | Â |
 All | 61.0 (48.0 to 86.0) | 87.0 (65.0 to 122.0) | 110.5 (81.0 to 153.0) | <0.0001 |
 Hgb ≤ 1,500 ng/ml | 61.0 (48.0 to 79.5) | 88.0 (65.0 to 126.0) | 109.0 (77.0 to 143.0) | <0.0001 |
p-tau181 (pg/ml)c | Â | Â | Â | Â |
 All | 20.0 (16.0 to 29.0) | 31.5 (21.0 to 45.0) | 36.0 (29.0 to 49.0) | <0.0001 |
 Hgb ≤ 1,500 ng/ml | 19.0 (15.0 to 26.5) | 31.0 (20.5 to 45.0) | 35.0 (28.0 to 46.5) | <0.0001 |