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Figure 7 | Alzheimer's Research & Therapy

Figure 7

From: β-amyloid deposition is shifted to the vasculature and memory impairment is exacerbated when hyperhomocysteinemia is induced in APP/PS1 transgenic mice

Figure 7

Matrix metalloproteinases 2 and 9 are activated by hyperhomocysteinemia in wild-type and APP/PS1 transgenic mice. (A) Graphed quantitative RT-PCR results for components of the matrix metalloproteinases 2 and 9 (MMP2 and MMP9) systems in both the wild-type (WT) and APP/PS1 mice. TIMP, Tissue inhibitor of metalloproteinase. **P < 0.01 compared to control (Cont) for the given genotype. (B) Gelatin zymogram color-inverted to highlight the digested bands in black. As indicated to the right, on the basis of molecular weight, we can determine that the bands highlighted correspond to pro-MMP9, MMP9, pro-MMP2 and MMP2. H, Hyperhomocysteinemia (HHcy) mice; C, control mice. (C) Quantification of band density for bands of interest highlighted in (B) for wild-type and control mice. *P < 0.05, **P < 0.01 compared to the control group for the given genotype (n = 16 for each wild-type group and n = 20 for each APP/PS1 group). Error bars show SEM.

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