From: Genetics of Alzheimer disease in the pre- and post-GWAS era
 | Non-ApoE hits | ApoE-related hits | |||
---|---|---|---|---|---|
Reference | Gene symbol | P valuea | Odds ratioa | P valuea | Odds ratioa |
Grupe et al. [50] | GALP, TNK1, chr14q32.13, PCK1, LMNA, PGBD1, LOC651924, chr7p15.2, THEM5, MYH13, CTSS, UBD, BCR, AGC1, TRAK2, EBF3 | 0.001 to 5.0 × 10-5 | 1.07 to 1.2 | 7.6 × 10-5 to 1.0 × 10-8 | 1.19 to 2.73 |
Coon et al. [51] |  |  |  | 1.1 × 10-39 | 4.01 |
Reiman et al. [52] | GAB2 | 9.7 × 10-11 | 4.06 | - | - |
Li et al. [53] | GOLPH2, chr9p24.3, chr15q21.2 | 9.8 × 10-3 to 4.5 × 10-6, b | 0.46 to 3.23b | 2.3 × 10-44 | - |
Abraham et al. [54] | LRAT | 3.4 × 10-6 to 6.1 × 10-7 | 1.2 to 1.3 | 4.8 × 10-6 to 4.0 × 10-14 | - |
Bertram et al. [55] | chr14q31.2, chr19q13.41 | 6.0 × 10-6 to 2.0 × 10-6 | 1.1 to 1.4c | 5.70 × 10-14 | - |
Beecham et al. [56] | 12q13 | 3.40 × 10-7 | - | - | - |
Feulner et al. [57] | MAPT, SORL1, CHRNB2, CH25H, GAB2, PGBD1, PCK1, LMNA | 0.05 to 6.8 × 10-3 | - | <1.0 × 10-6 to <1.0 × 10-40 | - |
Poduslo et al. [58] | TRPC4AP | 3.85 × 10-10 to 5.63 × 10-11, c 0.03d | 1.56d |  |  |
Carrasquillo et al. [59] | PCDH11X | 3.8 × 10-8 (0.08 to 5.4 × 10-13)e | 1.29 (1.17 to 1.75)e | 5.9 × 10-6 to 3.7 × 10-120 | 0.55 to 3.29 |
Harold et al. [60] | CLU | 8.5 × 10-10 (CLU) | 0.86 (CLU) | 3.4 × 10-8 to 1.8 × 10-157 | 0.63 to 2.5 |
 | PICALM | 1.3 × 10-9 (PICALM) | 0.86 (PICALM) |  |  |
Lambert et al. [61] | CLU | 7.5 × 10-9 (CLU) | 0.86 (CLU) | 5.06 × 10-7 to <2 × 10-16 | - |
 | CR1 | 3.7 × 10-9 (CR1) | 1.21 (CR1) |  |  |