Skip to main content
Figure 1 | Alzheimer's Research & Therapy

Figure 1

From: Acetylation: a new key to unlock tau’s role in neurodegeneration

Figure 1

Schematic diagram of the tau protein with post-translational modification sites. The molecular domains of the longest isoform of tau (4R2N) are depicted, which includes two amino-terminal inserts (N1 and N2) and four microtubule-binding domain repeats (R1 to R4). The post-translational modifications above the tau molecule depict phosphorylation (black font) and ubiquitination (red font) sites observed in pathological tau species purified from Alzheimer’s disease brain [38]. The post-translational modifications below the tau molecule illustrate the residues that are acetylated by both p300 and CREB-binding protein (black font) [4, 5], only p300 (blue font) [5], or only CREB-binding protein (green font) [4].

Back to article page