TMEM106B expression is reduced in Alzheimer’s disease brains

Table 1 Demographic profile of the cases examined in the present study

Case number	IHC	qPCR/WB	Cause of death	Brain weight (grams)	Postmortem interval (hours)	Braak staging (amyloid deposition/neurofibrillary degeneration)	pTDP-43 immunoreactivity		p.T185S genotype
							Frontal cortex	Hippocampus
NC1	+	+	Acute myocardial infarction	1,130	1.4	A/II	–	–	T/T
NC2	+	+	Acute myocardial infarction	1,350	1.6	0/II	–	–	T/S
NC3	+	+	Lung cancer	1,060	3.9	A/II	–	–	T/S
NC4	+	+	Dissecting aortic aneurysm	1,400	4.8	A/I	–	–	T/T
AD1	+	+	Pneumonia	1,000	1.1	C/VI	+	+	T/S
AD2		+	Pneumonia	1,230	14	C/VI			T/S
AD3	+	+	Pneumonia	1,220	10.5	C/VI	–	+	T/S
AD4	+	+	Pneumonia	1,240	8.1	C/VI	–	–	T/S
AD5	+	+	Lung cancer	1,090	4.5	C/VI	–	–	T/T
AD6	+	+	Pulmonary infarction	840	3	C/VI	–	+	T/S
AD7		+	Respiratory failure by aspiration	1,200	3.8	B/IV			T/S
AD8	+		Pneumonia	1,060	8	C/VI	–	+
PD1		+	Pneumonia	1,330	9.5	B/IV			S/S
PD2	+	+	Pneumonia	1,130	2.5	B/II	–	–	T/S
PD3	+	+	Respiratory failure by aspiration	910	2.5	B/II	–	–	T/S
PD4		+	Colon cancer	1,430	4	A/I			S/S
PD5	+		Pneumonia	1,320	9.3	C/III	–	–
ALS1	+	+	Respiratory failure	1,480	10.5	0/0	–	–	T/S
ALS2	+	+	Respiratory failure	1,090	1.3	0/I	+	+	T/T
ALS3	+	+	Respiratory failure	1,560	3	0/I	+	+	T/S
ALS4	+	+	Respiratory failure	1,320	10	0/II	+	–	S/S
ALS5		+	Respiratory failure	1,360	2.5	B/I			T/S
ALS6		+	Respiratory failure	1,600	13	B/I			T/S
MSA1	+		Pneumonia, septicemia	1,040	1.5	0/I	–	–
MSA2	+		Pneumonia	1,090	12	A/I	–	–

The demographic profile of the cases processed for immunohistochemistry (IHC), quantitative reverse transcriptase-polymerase chain reaction (qPCR), and western blotting (WB) is shown with the case number, the cause of death, brain weight, the postmortem interval, the Braak staging (amyloid deposition/neurofibrillary degeneration), phosphorylated TAR DNA-binding protein-43 (pTDP-43) immunoreactivity in the frontal cortex and the hippocampus, and the p.T185S genotype of the rs3173615 single nucleotide polymorphism. AD, Alzheimer’s disease; ALS, amyotrophic lateral sclerosis; MSA, multiple system atrophy; NC, non-neurological causes; PD, Parkinson’s disease.

ISSN: 1758-9193