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Figure 3 | Alzheimer's Research & Therapy

Figure 3

From: Progression of mild Alzheimer’s disease: knowledge and prediction models required for future treatment strategies

Figure 3

Prediction of cognitive outcome during three years of ChEI treatment. a) Predicted MMSE mean scores calculated from our non-linear regression model of ChEI-treated mild AD patients. The participants’ actual mean scores with 95% CI are also presented in the figure. The shaded area shows the decline of 1.4 to 1.8 MMSE points/year based on historical untreated individuals with mild AD [23]. b) Predicted ADAS-cog mean scores calculated from our non-linear regression model of ChEI-treated mild AD patients. Their actual mean scores with 95% CI are also presented in the figure. The mean predicted scores with 95% CI from two baseline-dependent prediction models of untreated AD patients are also included in the figure for comparison [24, 25]. AD, Alzheimer’s disease; ADAS-cog, Alzheimer’s Disease Assessment Scale-cognitive subscale; ChEI, cholinesterase inhibitor; MMSE, Mini-Mental State Examination.

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Alzheimer's Research & Therapy

ISSN: 1758-9193