From: Potential synergy between tau aggregation inhibitors and tau chaperonemodulators
Tau aggregation inhibitors | Family | Mechanism | Toxicity | BBB permeability | Other notes |
---|---|---|---|---|---|
AQ2S | Anthraquinone | β-sheet inhibitor | Nontoxic | Likely | Laxative |
Emodin | Anthraquinone | β-sheet inhibitor | Nontoxic | Likely | Laxative |
Daunorubicin | Anthraquinone | β-sheet inhibitor | Nontoxic | Likely | Laxative |
Mitoxantrone | Anthraquinone | β-sheet inhibitor | Nontoxic | Likely | Laxative |
Pixantrone | Anthraquinone | β-sheet inhibitor | Nontoxic | Likely | Laxative |
C11 | Carbocyanine | β-sheet inhibitor | Low toxicity | Likely |  |
N744 | Carbocyanine | β-sheet inhibitor | Low toxicity | Unknown |  |
PR-619 | Diaminopyridine | Hsp70 inhibitor | Some toxicity | Unknown | Â |
17-AAG | Natural product derivative | Hsp90 inhibitor | Some toxicity | Permeable | Low bioavailability |
Geldanamycin | Natural product | Hsp90 inhibitor | Highly toxic | Not permeable | Toxic |
Hydroxytyrosol | Natural product | β-sheet inhibitor | Nontoxic | Permeable |  |
Novobiocin | Natural product | Hsp90 inhibitor | Low toxicity | Poorly permeable | Â |
Oleuropein | Natural product | β-sheet inhibitor | Nontoxic | Not permeable |  |
Oleuropein aglyxone | Natural product | β-sheet inhibitor | Nontoxic | Unknown |  |
Radicicol | Natural product | Hsp90 inhibitor | Some toxicity | Poorly permeable | Low bioavailability |
Withaferin A | Natural product | Cdc37 inhibitor | Some toxicity | Permeable | Â |
Paclitaxel | Natural product | Microtubule stabilizer | Highly toxic | Poorly permeable | Â |
Curcumin | Natural product; flavonoid | Hsp70 inhibitor | Nontoxic | Permeable | Low bioavailability |
Myricetin | Natural product; flavonoid | Hsp70 inhibitor | Low toxicity | Permeable | Â |
Quercetin | Natural product; flavonoid | Hsp70 inhibitor | Low toxicity | Permeable | Â |
B1C11 | N-Phenylamine | β-sheet inhibitor | Low toxicity | Unknown |  |
B4A1 | N-Phenylamine | β-sheet inhibitor | Low toxicity | Unknown |  |
B4D3 | N-Phenylamine | β-sheet inhibitor | Low toxicity | Unknown |  |
B4D5 | N-Phenylamine | β-sheet inhibitor | Low toxicity | Unknown |  |
Methylene blue | Phenothiazine | Hsp70 inhibitor | Low toxicity | Permeable | Blue color |
Quinoxalines | Phenothiazine | Hsp70 inhibitor | Selective toxicity | Permeable | Low bioavailability |
BSc3094 | Phenylthiazolyl-hydrazides | β-sheet inhibitor | Some toxicity | Unknown |  |
Epalrestat | Rhodanine | β-sheet inhibitor | Some toxicity | Permeable | Aldose reductase inhibitor |
Troglitazone | Rhodanine | β-sheet inhibitor | Highly toxic | Likely |  |
MKT-077 | Rhodocyanine | Hsp70 inhibitor | Selective toxicity | Not permeable | Â |
YM-01 | Rhodocyanine | Hsp70 inhibitor | Selective toxicity | Not permeable | Â |
YM-08 | Rhodocyanine | Hsp70 inhibitor | Selective toxicity | Permeable | Less potent than YM-01 |
Macrocycles | Synthetic | β-sheet inhibitor | Unknown | Unknown |  |