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Figure 5 | Alzheimer's Research & Therapy

Figure 5

From: Simulations of symptomatic treatments for Alzheimer's disease: computational analysis of pathology and mechanisms of drug action

Figure 5

Working memory loss. Slope of working memory loss (defined as the decrease of working memory span per percent of deleted synapses) with increasing fractions of neuronal cell loss. It is clear that from 4% the decrease in performance accelerates substantially. As expected, having a greater cholinergic compensation tends to attenuate the decrease in working memory performance.

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