Table 1 Demographic characteristics of the cohort of 172 sequenced samples

Age at onset of AD

   Mean

   Standard deviation

   Range

Diagnosis

   Familial early-onset AD (onset ≤65 years)

   Sporadic early-onset AD (onset ≤65 years)

   Familial late-onset AD (onset >65 years)

   Clinical AD

   Autopsy-confirmed

APOE

   ε2ε2+ε2ε3

   ε3ε3

   ε3ε4

   ε4ε4

Birth country

   Spain

   Uruguay

Gender

   Male

   Female

   Unknown