Figure 2From: Pooled-DNA sequencing identifies novel causative variants in PSEN1, GRN and MAPT in a clinical early-onset and familial Alzheimer's disease Ibero-American cohortThe transcript of the novel GRN mutation. A splice-site mutation with a CC-insertion (g.10974_10975insCC) in GRN exon 8 results in a premature stop codon and nonsense-mediated decay of the resultant mRNA. GRN, progranulin.Back to article page