Alzheimer's Research & Therapy

Table 1 The levels of Aβ in the brains of mice of each genotype and age

From: Reduction of low-density lipoprotein receptor-related protein (LRP1) in hippocampal neurons does not proportionately reduce, or otherwise alter, amyloid deposition in APPswe/PS1dE9 transgenic mice

Age (month)	Cre	N	Aβ40 (pg/mg brain)			Aβ42 (pg/mg brain)			ratio 40/42
			Average	STDEV.P	P -value	Average	STDEV.P	P -value
8	-	3	1,257	1,022	0.40	271	193	0.45	4.6
	+	3	481	315		142	75		3.4
9	-	17	2,024	1,192	0.90	399	192	0.71	5.1
	+	12	2,074	746		421	116		4.9
15	-	4	4,235	946	0.65	1,015	104	0.74	4.2
	+	4	4,582	823		972	188		4.7
16 to 18	-	4	4,445	1,135	0.74	971	181	0.79	4.6
	+	5	4,830	1,777		1,020	289		4.7

There was no difference in the levels of Aβ40 and 42 in the brains of mouse expressing APPswe/PS1dE9 gene in the LRP1 lox/lox homozygous background in the absence or presence of the GFAP-Cre transgene in any given age group.

Back to article page

ISSN: 1758-9193

Contact us

General enquiries: journalsubmissions@springernature.com